A Novel Case of Four-Way Variant Translocation 46,XX,t(1,9,15,22) (p13;q34;q12,q11.2) In Chronic Myeloid Leukemia (CML); A Case Report

Authors

  • Željka Tkalčić Švabek Clinical Department of Laboratory Diagnostics, Division for Cytogenetics, University Hospital Centre Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia
  • Marina Josipović Department of Laboratory Diagnostics, General Hospital „Dr. Josip Benčević“, Andrije Štampara 42, 35000 Slavonski Brod, Croatia
  • Ivana Franić Šimić Clinical Department of Laboratory Diagnostics, Division for Cytogenetics, University Hospital Centre Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia
  • Ivana Vučinić Ljubičić Department of Hematology and Oncology, General Hospital „Dr. Josip Benčević“, Andrije Štampara 42, 35000 Slavonski Brod, Croatia

DOI:

https://doi.org/10.15520/jro.v6i11.33

Keywords:

bone marrow; chronic myelogenous leukemia; cytogenetics; Philadelphia chromosome

Abstract

The main characteristic of chronic myeloid leukemia (CML) is the Philadephia chromosome (Ph) formed by translocation of chromosomes 9 and 22. However, 5-8% of patients have a variant translocation involving one or more different chromosomes. In this case, a blood count for a 56-year-old patient showed low levels of hemoglobin and platelets with high leukocytes and further hematological examination diagnosed CML. Cytogenetic analysis of bone marrow (BM) showed a complex four-way karyogram 46,XX,t(1,9,15,22)(p13;q34;q12,q11.2) and Ph positive chromosome, which we present in this study.

Downloads

Download data is not yet available.

Downloads

Published

2019-11-01

Issue

Vol. 6 No. 11 (2019)

Section

Research Articles | Open access

How to Cite

1.
A Novel Case of Four-Way Variant Translocation 46,XX,t(1,9,15,22) (p13;q34;q12,q11.2) In Chronic Myeloid Leukemia (CML); A Case Report . Journal of Research and Opinion [Internet]. 2019 Nov. 1 [cited 2026 Oct. 24];6(11):2561-4. Available from: http://researchopinion.in/index.php/jro/article/view/33