A Novel Case of Four-Way Variant Translocation 46,XX,t(1,9,15,22) (p13;q34;q12,q11.2) In Chronic Myeloid Leukemia (CML); A Case Report
- Articles
- Submited: November 1, 2019
-
Published: November 1, 2019
Abstract
The main characteristic of chronic myeloid leukemia (CML) is the Philadephia chromosome (Ph) formed by translocation of chromosomes 9 and 22. However, 5-8% of patients have a variant translocation involving one or more different chromosomes. In this case, a blood count for a 56-year-old patient showed low levels of hemoglobin and platelets with high leukocytes and further hematological examination diagnosed CML. Cytogenetic analysis of bone marrow (BM) showed a complex four-way karyogram 46,XX,t(1,9,15,22)(p13;q34;q12,q11.2) and Ph positive chromosome, which we present in this study.
Article Metrics Graph
References
1. Kang ZJ, Liu YF, Xu LZ, Long ZJ, Huang D, Yang Y, et al.The Philadelphia chromosome in leukemogenesis. Chin J Cancer 2016; 35:48.
2. Costa D, Grau J, Espinet B, Arias A, Gómez C, Lopez-Guerra M et al. Conventional and molecular cytogenetic studies to characterize 32 complex variant Philadelphia translocations in patients with chronic myeloid leukemia. Oncol Lett, 2019; 5705-5710.
3. Sweet K, Zhang L, Pinilla-Ibarz J. Biomarkers for determining the prognosis in chronic myelogenous leukemia. J Hematol Oncol. 2013; 6:54.
4.Marzocchi G, Castagenetti F, Luatti S, Baldazzi C, Stacchini M, Gugliotta G, et al. Variant Philadelphia translocations: molecular-cytogenetic characterization and prognostic influence on frontline imatinib therapy, a GIMEMA Working Party on CML analysis.Blood 2011 117:6793-6800.
5. Rooney DE. Human cytogenetics: malignancy and acquired abnormalities. Oxford, UK: Oxford University Press.
6. McGowan-Jordan, J. Simons, A. Schmid, M. ISCN 2016: An International System for Human Cytogenomic Nomenclature (2016). Basel, New York; Karger Publising.
7. Bennour A, Sennana H, Laatiri MA, Elloumi M, Khelif A, Saad A. Molecular cytogenetic characterization of variant Philadelphia translocations in chronic myeloid leukemia: Genesis and deletion of derivative chromosome 9. Cancer Genet Cytogenet 2009; 194:30-7.
8. Eyupoglu D, Bozkurt S, Haznedaroglu I, Buyukasik Y, Guven D. The impact of variant Philadelphia chromosome translocations on the clinical course of chronic myeloid leukemia. Turk J Haematol. 2016 Mar 5; 33(1):60–5.
9. Jabbour E, Kantarjian H. Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring. Am J Hematol. 2018 Mar; 93(3):442-459.
10. Stagno F, Vigneri P, Del Fabro V, Stella S, Cupri A, Massimino M, et al. Influence of complex variant chromosomal translocations in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors. Acta Oncol 2010; 49:506-8.
11. Mitelman F, Johansson B and Mertens F. Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer (2019). http://cgap.nci.nih.gov/Chromosomes/Mitelman.
2. Costa D, Grau J, Espinet B, Arias A, Gómez C, Lopez-Guerra M et al. Conventional and molecular cytogenetic studies to characterize 32 complex variant Philadelphia translocations in patients with chronic myeloid leukemia. Oncol Lett, 2019; 5705-5710.
3. Sweet K, Zhang L, Pinilla-Ibarz J. Biomarkers for determining the prognosis in chronic myelogenous leukemia. J Hematol Oncol. 2013; 6:54.
4.Marzocchi G, Castagenetti F, Luatti S, Baldazzi C, Stacchini M, Gugliotta G, et al. Variant Philadelphia translocations: molecular-cytogenetic characterization and prognostic influence on frontline imatinib therapy, a GIMEMA Working Party on CML analysis.Blood 2011 117:6793-6800.
5. Rooney DE. Human cytogenetics: malignancy and acquired abnormalities. Oxford, UK: Oxford University Press.
6. McGowan-Jordan, J. Simons, A. Schmid, M. ISCN 2016: An International System for Human Cytogenomic Nomenclature (2016). Basel, New York; Karger Publising.
7. Bennour A, Sennana H, Laatiri MA, Elloumi M, Khelif A, Saad A. Molecular cytogenetic characterization of variant Philadelphia translocations in chronic myeloid leukemia: Genesis and deletion of derivative chromosome 9. Cancer Genet Cytogenet 2009; 194:30-7.
8. Eyupoglu D, Bozkurt S, Haznedaroglu I, Buyukasik Y, Guven D. The impact of variant Philadelphia chromosome translocations on the clinical course of chronic myeloid leukemia. Turk J Haematol. 2016 Mar 5; 33(1):60–5.
9. Jabbour E, Kantarjian H. Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring. Am J Hematol. 2018 Mar; 93(3):442-459.
10. Stagno F, Vigneri P, Del Fabro V, Stella S, Cupri A, Massimino M, et al. Influence of complex variant chromosomal translocations in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors. Acta Oncol 2010; 49:506-8.
11. Mitelman F, Johansson B and Mertens F. Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer (2019). http://cgap.nci.nih.gov/Chromosomes/Mitelman.
How to Cite
1.
A Novel Case of Four-Way Variant Translocation 46,XX,t(1,9,15,22) (p13;q34;q12,q11.2) In Chronic Myeloid Leukemia (CML); A Case Report . Journal of Research and Opinion [Internet]. 2019 Nov. 1 [cited 2024 Nov. 21];6(11):2561-4. Available from: https://researchopinion.in/index.php/jro/article/view/33
